This is the fourteenth in a series of Annual Conferences supported by the European Commission, which regularly attracts over 500 delegates from commercial, government and research organisations around the world. Focusing on eBusiness, eGovernment, eWork, eEurope 2005 and ICT take-up by SMEs and International Collaboration on IST, the goal of e-2004 is to stimulate rapid take-up of Research and Technology Development (RTD) results by European industry, and SMEs in particular.